Endocrine Abstracts

BACKGROUND: Atherosclerosis is a major cause of mortality in diabetes mellitus. Gene therapy may be a useful approach to the treatment of this disorder. One of the main obstacles to the use of this therapeutic modality is the difficulty in obtaining safe and efficient gene transfer in vivo. Adenoassociated virus vector have been used in a number of previous studies but have never been used for vascular gene delivery. OBJECTIVE: Our goal was to characterize AAV mediated gene de...

BACKGROUND: Atherosclerosis is a major cause of mortality in diabetes mellitus. Gene therapy may be a useful approach to the treatment of this disorder. One of the main obstacles to the use of this therapeutic modality is the difficulty in obtaining safe and efficient gene transfer in vivo. Adenoassociated virus vector have been used in a number of previous studies but have never been used for vascular gene delivery. OBJECTIVE: Our goal was to characterize AAV mediated gene de...